Isotopically Labeled Compounds
Medchemexpress LLC Trabectedin-d3 (Ecteinascidin 743-d3) | 114899-77-3 | 99.1% | C39H40D3N3O11S | 1 MG
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin, a tetrahydroisoquinoline alkaloid with potent antitumor activity. It binds to the minor groove of DNA, blocking transcription of stress-induced proteins, inducing DNA backbone cleavage, and cancer cell apoptosis. It also increases the generation of reactive oxygen species (ROS) in MCF-7 and MDA-MB-453 cells. This product has potential for soft tissue sarcoma and ovarian cancer treatment and is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Tetracosane-d50 | 16416-32-3 | 5 MG
Tetracosane-d50 is the deuterium labeled Tetracosane, intended for research purposes only and not for patient use. It serves as a tracer and an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS. Deuteration, the incorporation of stable heavy isotopes into drug molecules, is commonly used for quantitation during drug development and can influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
![Revvity Health Sciences Inc dCTP, [α-<sup>32</sup>P]- 6000Ci/mmol 20mCi/ml EasyTide, 250 µCi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502809543.jpg-250.jpg)
Revvity Health Sciences Inc dCTP, [α-32P]- 6000Ci/mmol 20mCi/ml EasyTide, 250 µCi
dCTP, [α-32P]- 6000Ci/mmol 20mCi/ml EasyTide, 250 µCi
Medchemexpress LLC Climbazole-d4 | 1185117-79-6 | 99.9% | 1 MG
Climbazole-d4 is a deuterium-labeled version of Climbazole. Climbazole is recognized as a potent antifungal agent and also acts as a strong inducer of rat hepatic cytochrome P450. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules, primarily to serve as tracers for quantitative analysis during drug development, and this substitution can influence the pharmacokinetic and metabolic profiles of drugs.
- Is a deuterium-labeled compound.
- The parent compound is a potent antifungal agent.
- Is also a potent inducer of rat hepatic cytochrome P450.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques like NMR, GC-MS, or LC-MS.
Medchemexpress LLC Glyburide-d3 (deuterium-labeled glibenclamide) | 1219803-02-7 | MFCD06658648 | 99.6% | 497.02 | C23H25D3ClN3O5S | 10 MG
Glyburide-d3 is the deuterium-labeled isotopologue of glibenclamide supplied as a solid research reagent and analytical standard. It serves as a labeled internal standard and is used in studies of ATP-sensitive K+ (KATP) channel activity and related analytical workflows.
- Deuterium-labeled internal standard for analytical assays.
- High purity: 99.64%.
- CAS number: 1219803-02-7.
- Molecular weight: 497.02; chemical formula: C23H25D3ClN3O5S.
- Appearance: white to off-white solid.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Solubility: DMSO 100 mg/mL; H2O 0.1 mg/mL (ultrasonic/warming recommended).
Medchemexpress LLC Buspirone-d8 hydrochloride | 1216761-39-5 | CB0105448 | 500 UG
Buspirone-d8 hydrochloride is the deuterium labeled Buspirone hydrochloride. It is an anxiolytic psychotropic agent primarily used to treat generalized anxiety disorder (GAD).
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories SPECTRA 9 (13C, 98%; D, 97%+; 15N, 98%), 1 L
SPECTRA 9 (13C, 98%; D, 97%+; 15N, 98%), 1 L
Medchemexpress LLC Phenanthrene-d10 | 1517-22-2 | MFCD00039418 | 99.5% | 25 MG
Phenanthrene-d10 is the deuterium-labeled Phenanthrene, a polycyclic aromatic hydrocarbon (PAH) frequently used as an indicator for monitoring PAH contaminated matrices. It induces oxidative stress and inflammation and is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Donepezil-d7 hydrochloride | 1261394-20-0 | 420782 | 99.0% | C24H23D7ClNO3 | 2.5 MG
Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. It is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories 2-HEDTA (2-HYDROXYETHYL-D4, 98%), 0.5 G, 203805-99-6
2-HEDTA (2-HYDROXYETHYL-D4, 98%), 0.5 G, 203805-99-6
Medchemexpress LLC N-acetylisoniazid-d4 | 1330169-81-7 | 183.20 g/mol | C8H5D4N3O2 | 1 MG
Deuterium-labeled acetylisoniazid provided as a research-grade reference standard for analytical and metabolic investigations. Intended for use as an internal standard in mass spectrometry, tracer experiments, and method development. Purity and recommended storage conditions are supplied in the Certificate of Analysis.
Cambridge Isotope Laboratories CHLOROMETHANE-D3 (D, 99%), 1 L, 1111-89-3
CHLOROMETHANE-D3 (D, 99%), 1 L, 1111-89-3. **This item is shipped in a Code M lecture bottle. The fee for the bottle will need added to the order as a separate charge. Please include part# NC1539013 to the order.
Medchemexpress LLC Methanol-d1 | 1455-13-6 | MFCD00044213 | ≥99.0% | 33.048 g/mol | CH3OD | 100 G
Methanol-d1 (CH3OD) is deuterium-labeled methanol intended for use as a tracer and as an internal standard in NMR, GC-MS, and LC-MS quantitative analyses. The reagent is provided with high isotopic and chemical purity and is suitable for routine analytical workflows.
- High isotopic purity (≥99.0%) for accurate quantitative analysis.
- Compatible with NMR, GC-MS, and LC-MS methodologies.
- Available in multiple laboratory sizes, including 100 g.
- Formula CH3OD enables straightforward solvent substitution in protocols.
- Stable under recommended storage conditions with extended shelf life.
Cambridge Isotope Laboratories POTASSIUM CYANIDE (13C, 99%; 15N, 98%+), 1 G, 74889-51-3
POTASSIUM CYANIDE (13C, 99%; 15N, 98%+), 1 G, 74889-51-3
Cayman Chemical rac-Aprepitant-d4, Purity: ≥99% deuterated forms (d1-d4), CAS: 2748471-42-1, 1 mg
An internal standard for the quantification of aprepitant by GC- or LC-MS